Juxtapid is a pill you take once a day

Juxtapid offers flexible dosing so your doctor can customize your dose—and change it if needed. Your doctor will likely start you on a low dose of 5 mg per day. Depending on your cholesterol goals, your liver test results, and how well you tolerate Juxtapid, your doctor may increase or decrease your dose.

5mg
10mg
20mg
30mg
40mg
60mg

 

Everyone responds differently to treatment. When just starting Juxtapid, some people see results right away, others only see small reductions, some don’t see any change, and others don’t see changes until after their dose is increased. It’s important to work with your doctor to find the dose that’s right for you.

With Juxtapid, you can feel confident that your doctor has options to find the dose that’s right for you.

Select Important Safety Information

Juxtapid may cause serious side effects including:

  • Stomach problems can also be a symptom of liver problems. Tell your doctor right away if you have nausea; vomiting or stomach pain that gets worse, does not go away, or changes; fever; yellowing of your eyes or skin; feeling more tired than usual; or having flu-like symptoms while taking Juxtapid because these may be signs of liver problems.
  • Do not drink more than 1 alcoholic drink per day while taking Juxtapid.
I’m on the 20 mg dose now. I started at 5, went to 10, and at 20, my doctor and I decided that was the right dose for me.
Stacee, Diagnosed with HoFH
Individual results may vary.

How do I take Juxtapid?

Always take medications exactly as instructed by your doctor. Below are some important things to keep in mind while taking Juxtapid.

DO
  • Do take by mouth, with a glass of water
  • Do take on an empty stomach (at least 2 hours after dinner or evening snack)
  • Do store Juxtapid at room temperature and keep in a tightly closed container
  • Do maintain a low-fat eating plan
DON'T
  • Don’t take Juxtapid with food
  • Don’t drink more than 1 alcoholic drink per day
  • Don’t drink grapefruit juice or eat grapefruit
  • Why? Grapefruit juice and alcohol can alter the way the liver responds to some medications, including Juxtapid.

Juxtapid makes it harder for some fat-soluble nutrients, such as vitamin E and fatty acids, to get into your body. Take supplements that contain fat-soluble vitamins each day while you take Juxtapid. Ask your doctor, nurse, or dietitian how to take them.

Potential stomach problems

In addition to working in the liver, Juxtapid works in the small intestine and changes the way your body absorbs fat.

Fat from the foods you eat can’t be absorbed as easily when you are taking Juxtapid. If you eat too much fat, you may experience problems such as diarrhea and bloating. Maintaining a low-fat eating plan may help to lower the chance of stomach problems.

Talk to your dietitian

A specially trained Compass Registered Dietitian will work with you to help you find simple ways to adapt your current diet to the Juxtapid low-fat eating plan as easily as possible.

Other things you can do:

Keep a log of the foods you eat and the amount of fat they contain so you are sure you are staying below your daily maximum. This is especially important when you’re first starting out and when your dose is increased.

If you experience stomach issues, there may be ways to help reduce them. Check in with your Compass Registered Dietitian for tips on how to adjust your eating plan to help minimize stomach issues associated with fat intake. Your doctor can also provide suggestions on managing these side effects.

Select Important Safety Information

Juxtapid may cause serious side effects including:

Harm to your unborn baby

  • Do not take Juxtapid if you are pregnant, think you may be pregnant, or are planning to become pregnant.
  • You should have a negative pregnancy test result before you start on Juxtapid. Use effective birth control while taking Juxtapid. If you become pregnant while taking Juxtapid, stop taking Juxtapid and call your doctor right away.
I made a couple of mistakes and had some stomach problems when I first started taking Juxtapid. But now that I’ve gotten used to the low-fat eating plan, it’s no longer a problem for me.
Andrea, Diagnosed with HoFH
Individual results may vary.

Compass | 1-85-JUXTAPID

Juxtapid may cause liver problems.

Important Safety Information

Juxtapid is available only through certified pharmacies that are enrolled in the Juxtapid REMS Program. Your doctor must be enrolled and certified in the program in order to prescribe Juxtapid.

Juxtapid may cause serious side effects, including:
Liver Problems

  • Juxtapid can cause liver problems such as increased liver enzymes or increased fat in the liver. For this reason, your doctor should do blood tests to check your liver before you start Juxtapid and while you are taking Juxtapid (especially if your dose is increased). If your tests show signs of liver problems, your doctor may lower your dose of Juxtapid or stop it altogether.
  • You should tell your doctor if you have had liver problems in the past, including liver problems while taking other medicines.
  • Stomach problems can also be a symptom of liver problems. Tell your doctor right away if you have nausea; vomiting or stomach pain that gets worse, does not go away, or changes; fever; yellowing of your eyes or skin; feeling more tired than usual; or having flu-like symptoms while taking Juxtapid because these may be signs of liver problems.
  • Do not drink more than 1 alcoholic drink per day while taking Juxtapid.

Harm to your unborn baby

  • Do not take Juxtapid if you are pregnant, think you may be pregnant, or are planning to become pregnant.
  • You should have a negative pregnancy test result before you can start on Juxtapid. Use effective birth control while taking Juxtapid. If you become pregnant while taking Juxtapid, stop taking Juxtapid and call your doctor right away.

You should not take Juxtapid if you:

  • Are taking medications known as moderate or strong CYP3A4 inhibitors (for example, certain medications used to treat bacterial, fungal, or viral infections, as well as certain medications used to treat depression, high blood pressure, or angina). These medications may affect how your body breaks down Juxtapid.
  • Have moderate to severe liver problems or active liver disease, including abnormal liver function tests.

Other possible side effects of Juxtapid:

  • The most common side effects of Juxtapid are stomach problems including diarrhea, nausea, vomiting, cramps/pain, indigestion, and/or gas. You may be able to reduce your chance of stomach problems by following an eating plan consisting of less than 20% of calories from fat.
  • Juxtapid makes it harder for some fat-soluble nutrients, such as vitamin E and fatty acids, to get into your body. Take supplements that contain fat-soluble vitamins each day while you take Juxtapid. Ask your doctor, nurse, or dietitian how to take them.

Tell your doctor if you have any side effect that bothers you or that does not go away. Stop taking Juxtapid and tell your doctor if you have severe diarrhea, especially if you also have lightheadedness, decreased urine output, or tiredness. These are not all the possible side effects of Juxtapid. For more information, speak with your doctor or pharmacist.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Juxtapid may affect the way other medicines work, and other medicines may affect how Juxtapid works.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or
call 1-800-FDA-1088.

This is the most important information about Juxtapid. For more detailed information, Please see the Medication Guide, Instructions for Use and full Prescribing Information including Box Warning.