The narrowing and hardening of arteries, caused by high cholesterol in the blood, which limits the flow of blood to organs and other parts of the body.


A substance made mainly by the liver, but also found in some foods, that circulates in the blood. The body needs cholesterol to stay healthy, but too little of one type and too much of another can cause health problems. Also see LDL.

Compass Care Manager

Member of your dedicated Compass team who works to help make the insurance process easier for you, helps you understand the cost of your treatment, and can refer you to independent financial assistance programs.

Compass Registered Dietitian

Member of your dedicated Compass team who consults with you to customize a low-fat eating plan that works for you when you're first starting Juxtapid and as you continue to take Juxtapid.

FH (familial hypercholesterolemia)

A serious health condition in which high cholesterol is caused by defective genes rather than poor diet or lack of exercise. Also see HoFH.


A part of a cell passed down by parents that determines the traits and features of their children.


Relating to something you inherited from your parents. If a health problem is genetic, it means you inherited the problem genes from at least one of your parents.

HeFH (heterozygous familial hypercholesterolemia)

A serious inherited condition in which the problem genes are passed down from one side of the family and cause high cholesterol. Studies have not been conducted to tell us whether Juxtapid is safe for use in people with high cholesterol that do not have HOFH, including those with HeFH.

HoFH (homozygous familial hypercholesterolemia)

A serious inherited condition in which the problem genes are passed down from both sides of the family and cause high cholesterol. HoFH is the least common and most severe form of FH.


Something passed down through one or both of your parents' genes. If a health problem is inherited, it means a problem gene caused it.

LDL (low-density lipoprotein) cholesterol

Also known as “bad“ cholesterol. If LDL cholesterol is too high, it can build up in arteries, and may cause health problems.

Liver monitoring

When taking certain medications such as Juxtapid®, your doctor will perform blood tests to check if your liver is functioning normally, as well as look for signs of liver problems.

Low-fat eating plan

While many people with high cholesterol are encouraged to stick to a heart-healthy diet, the Juxtapid low-fat eating plan is somewhat different because it is intended to help people avoid common stomach problems such as diarrhea and nausea.

Registered dietitian

An expert in proper nutrition and specialized diets (for example, a heart-healthy or gluten-free diet). Dietitians help people develop an eating plan based on their specific dietary needs and preferences.

Safety phase

A part of a study that is designed to monitor the safety and tolerability of a specific drug.


Prescription medicines that are used to reduce the amount of bad (LDL) cholesterol in the blood in the general population.

Compass | 1-85-JUXTAPID

Juxtapid may cause liver problems.

Important Safety Information

Juxtapid is available only through certified pharmacies that are enrolled in the Juxtapid REMS Program. Your doctor must be enrolled and certified in the program in order to prescribe Juxtapid.

Juxtapid may cause serious side effects, including:
Liver Problems

  • Juxtapid can cause liver problems such as increased liver enzymes or increased fat in the liver. For this reason, your doctor should do blood tests to check your liver before you start Juxtapid and while you are taking Juxtapid (especially if your dose is increased). If your tests show signs of liver problems, your doctor may lower your dose of Juxtapid or stop it altogether.
  • You should tell your doctor if you have had liver problems in the past, including liver problems while taking other medicines.
  • Stomach problems can also be a symptom of liver problems. Tell your doctor right away if you have nausea; vomiting or stomach pain that gets worse, does not go away, or changes; fever; yellowing of your eyes or skin; feeling more tired than usual; or having flu-like symptoms while taking Juxtapid because these may be signs of liver problems.
  • Do not drink more than 1 alcoholic drink per day while taking Juxtapid.

Harm to your unborn baby

  • Do not take Juxtapid if you are pregnant, think you may be pregnant, or are planning to become pregnant.
  • You should have a negative pregnancy test result before you can start on Juxtapid. Use effective birth control while taking Juxtapid. If you become pregnant while taking Juxtapid, stop taking Juxtapid and call your doctor right away.

You should not take Juxtapid if you:

  • Are taking medications known as moderate or strong CYP3A4 inhibitors (for example, certain medications used to treat bacterial, fungal, or viral infections, as well as certain medications used to treat depression, high blood pressure, or angina). These medications may affect how your body breaks down Juxtapid.
  • Have moderate to severe liver problems or active liver disease, including abnormal liver function tests.

Other possible side effects of Juxtapid:

  • The most common side effects of Juxtapid are stomach problems including diarrhea, nausea, vomiting, cramps/pain, indigestion, and/or gas. You may be able to reduce your chance of stomach problems by following an eating plan consisting of less than 20% of calories from fat.
  • Juxtapid makes it harder for some fat-soluble nutrients, such as vitamin E and fatty acids, to get into your body. Take supplements that contain fat-soluble vitamins each day while you take Juxtapid. Ask your doctor, nurse, or dietitian how to take them.

Tell your doctor if you have any side effect that bothers you or that does not go away. Stop taking Juxtapid and tell your doctor if you have severe diarrhea, especially if you also have lightheadedness, decreased urine output, or tiredness. These are not all the possible side effects of Juxtapid. For more information, speak with your doctor or pharmacist.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Juxtapid may affect the way other medicines work, and other medicines may affect how Juxtapid works.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or
call 1-800-FDA-1088.

This is the most important information about Juxtapid. For more detailed information, Please see the Medication Guide, Instructions for Use and full Prescribing Information including Box Warning.