Atherosclerosis

The narrowing and hardening of arteries, caused by high cholesterol in the blood, which limits the flow of blood to organs and other parts of the body.

Cholesterol

A substance made mainly by the liver, but also found in some foods, that circulates in the blood. The body needs cholesterol to stay healthy, but too little of one type and too much of another can cause health problems. Also see LDL.

Compass Care Manager

Member of your dedicated Compass team who works to help make the insurance process easier for you, helps you understand the cost of your treatment, and can refer you to independent financial assistance programs.

Compass Patient Education Manager

Member of your dedicated Compass team who provides education about HoFH, Juxtapid and the process of starting and staying on treatment.

Compass Registered Dietitian

Member of your dedicated Compass team who consults with you to customize a low-fat eating plan that works for you when you're first starting Juxtapid and as you continue to take Juxtapid.

FH (familial hypercholesterolemia)

A serious health condition in which high cholesterol is caused by defective genes rather than poor diet or lack of exercise. Also see HoFH.

Gene

A part of a cell passed down by parents that determines the traits and features of their children.

Genetic

Relating to something you inherited from your parents. If a health problem is genetic, it means you inherited the problem genes from at least one of your parents.

HoFH (homozygous familial hypercholesterolemia)

A serious inherited condition in which the problem genes are passed down from both sides of the family and cause high cholesterol. HoFH is the least common and most severe form of FH.

Inherited

Something passed down through one or both of your parents' genes. If a health problem is inherited, it means a problem gene caused it.

LDL (low-density lipoprotein) cholesterol

Also known as “bad“ cholesterol. If LDL cholesterol is too high, it can build up in arteries, and may cause health problems.

Liver monitoring

When taking certain medications such as Juxtapid®, your doctor will perform blood tests to check if your liver is functioning normally, as well as look for signs of liver problems.

Low-fat eating plan

While many people with high cholesterol are encouraged to stick to a heart-healthy diet, the Juxtapid low-fat eating plan is somewhat different because it is intended to help people avoid common stomach problems such as diarrhea and nausea.

Safety phase

A part of a study that is designed to monitor the safety and tolerability of a specific drug.

Statins

Prescription medicines that are used to reduce the amount of bad (LDL) cholesterol in the blood in the general population. People with HoFH may be able to reduce bad (LDL) cholesterol levels to a certain degree with statins, but adding an HoFH-specific treatment may help them get closer to their cholesterol goal.

What is Juxtapid?

Juxtapid® (lomitapide) capsules is a prescription medicine used along with diet and other lipid-lowering treatments, including low-density lipoprotein (LDL) apheresis where available, in adults with homozygous familial hypercholesterolemia (HoFH) to reduce LDL (“bad”) cholesterol, total cholesterol, a protein that carries bad cholesterol in the blood (apolipoprotein B), and non-high-density lipoprotein cholesterol (non-HDL-C).

Studies have not been conducted to tell us whether Juxtapid can help prevent problems from high cholesterol, such as heart attack, stroke, death, or other health problems. Studies have also not been conducted to tell us whether Juxtapid is safe for use in people with high cholesterol who do not have HoFH, including those with heterozygous familial hypercholesterolemia (HeFH).

IMPORTANT SAFETY INFORMATION

Juxtapid is available only through certified pharmacies that are enrolled in the Juxtapid REMS Program. Your doctor must be enrolled and certified in the program in order to prescribe Juxtapid.

Juxtapid may cause serious side effects including:

Liver problems

  • Juxtapid can cause liver problems such as increased liver enzymes or increased fat in the liver. For this reason, your doctor should do blood tests to check your liver before you start Juxtapid and while you are taking Juxtapid (especially if your dose is increased). 
  • You should tell your doctor if you have had liver problems in the past, including liver problems while taking other medicines.
  • Stomach problems can also be a symptom of liver problems. Tell your doctor right away if you have nausea; vomiting or stomach pain that gets worse, does not go away, or changes; fever; yellowing of your eyes or skin; feeling more tired than usual; or having flu-like symptoms while taking Juxtapid because these may be signs of liver problems.
  • Do not drink more than 1 alcoholic drink per day while taking Juxtapid.

Harm to your unborn baby

  • Do not take Juxtapid if you are pregnant, think you may be pregnant, or are planning to become pregnant.
  • You should have a negative pregnancy test result before you can start on Juxtapid. Use effective birth control while taking Juxtapid. If you become pregnant while taking Juxtapid, stop taking Juxtapid and call your doctor right away.

You should not take Juxtapid if you

  • Are taking medications known as moderate or strong CYP3A4 inhibitors (for example, certain medications used to treat bacterial, fungal, or viral infections, as well as certain medications used to treat depression, high blood pressure, or angina). These medications may affect how your body breaks down Juxtapid.
  • Have moderate to severe liver problems or active liver disease, including abnormal liver function tests.

Other possible side effects of Juxtapid:

  • The most common side effects of Juxtapid are stomach problems including diarrhea, nausea, vomiting, cramps/pain, indigestion, and/or gas. You may be able to reduce your chance of stomach problems by following an eating plan consisting of less than 20% of calories from fat.
  • Juxtapid makes it harder for some fat-soluble nutrients, such as vitamin E and fatty acids, to get into your body. Take supplements that contain fat-soluble vitamins each day while you take Juxtapid. Ask your doctor, nurse, or dietitian how to take them.

Tell your doctor if you have any side effect that bothers you or that does not go away. Stop taking Juxtapid and tell your doctor if you have severe diarrhea, especially if you also have lightheadedness, decreased urine output, or tiredness. These are not all the possible side effects of Juxtapid. For more information, speak with your doctor or pharmacist.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Juxtapid may affect the way other medicines work, and other medicines may affect how Juxtapid works.

You are encouraged to report negative side effects of prescription drugs to your doctor. You may also report side effects to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.

This is the most important information about Juxtapid. For more detailed information, please see the Medication Guide and Prescribing Information.

All people featured on this site are real patients living with HoFH and were taking Juxtapid at the time of the photo shoot.

 

This information is intended for US healthcare providers

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This information is intended for US healthcare providers

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